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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P15538: Variant p.Cys10Tyr

Cytochrome P450 11B1, mitochondrial
Gene: CYP11B1
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Variant information Variant position: help 10
Type of variant: help LB/B
Residue change: help From Cysteine (C) to Tyrosine (Y) at position 10 (C10Y, p.Cys10Tyr).
Physico-chemical properties: help Change from medium size and polar (C) to large size and aromatic (Y)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 10
Protein sequence length: help 503
Location on the sequence: help MALRAKAEV C MAVPWLSLQRAQALGTRAAR
Residue conservation: help 
Human                         MALRAKAEVCMAVPWLSLQRAQALGTRAAR

Rat                           MALRVTADVWLARPWQCLHRTRALGTTAKV

Pig                           MAIWAKAEAWLAGPWLALNRARTLGTRAVL

Bovine                        MALWAKARVRMAGPWLSLHEARLLGTRGAA

Sheep                         MALWAKARVWMAGPWLSLHRARPLGTRASA
Sequence annotation in neighborhood: help
TypePositionsDescription
Transit peptide 1 – 24 Mitochondrion



Literature citations
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Cargill M.; Altshuler D.; Ireland J.; Sklar P.; Ardlie K.; Patil N.; Shaw N.; Lane C.R.; Lim E.P.; Kalyanaraman N.; Nemesh J.; Ziaugra L.; Friedland L.; Rolfe A.; Warrington J.; Lipshutz R.; Daley G.Q.; Lander E.S.;
Nat. Genet. 22:231-238(1999)
Cited for: VARIANTS TYR-10; GLN-43; THR-348 AND VAL-386;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.