Variant position: 460 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 737 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QQREKTRWLNSGRGDEASEE GQNGSSPKSKTKWTKEDGHRT
Mouse QQREKTRWLHSGRGDDASEE GQNGSSPKSKTKWTKEDGHRT
Rat QQREKTRWLNSGRGDDASEE GQNGSSPKSKTKWTKEDGHRT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 737 Alpha-adducin
421 – 486 Disordered
445 – 445 Phosphothreonine; by ROCK2
464 – 464 Phosphoserine
465 – 465 Phosphoserine
480 – 480 Phosphothreonine; by ROCK2
471 – 471 K -> KVWTNITHDHVKPLLQSLSSGVCVPSCITNCL. In isoform 3 and isoform 6.
445 – 445 T -> D. Abolishes phosphorylation by ROCK2; when associated with D-480.
480 – 480 T -> D. Abolishes phosphorylation by ROCK2; when associated with D-445.
Human alpha-adducin gene, blood pressure, and sodium metabolism.
Kamitani A.; Wong Z.Y.; Fraser R.; Davies D.L.; Connor J.M.; Foy C.J.; Watt G.C.; Harrap S.B.;
Cited for: VARIANT TRP-460;
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Halushka M.K.; Fan J.-B.; Bentley K.; Hsie L.; Shen N.; Weder A.; Cooper R.; Lipshutz R.; Chakravarti A.;
Nat. Genet. 22:239-247(1999)
Cited for: VARIANTS TRP-460 AND CYS-586;
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