Variant position: 586 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 737 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TLTDRELEEYRREVERKQKG SEENLDEAREQKEKSPPDQPA
Mouse TLTDRELEEYRREVERKQKG SEENLDETREQKEKSPPDQSA
Rat TLTDRELEEYRREVERKQKG SEENLDETREQKEKSPPDQSA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 737 Alpha-adducin
576 – 737 Disordered
576 – 602 Basic and acidic residues
586 – 586 Phosphoserine
600 – 600 Phosphoserine
512 – 737 Missing. In isoform 5.
Primary structure and domain organization of human alpha and beta adducin.
Joshi R.L.; Gilligan D.M.; Otto E.; McLaughlin T.; Bennett V.D.;
J. Cell Biol. 115:665-675(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); PROTEIN SEQUENCE OF 24-36; 41-47; 516-569 AND 722-729; VARIANT CYS-586;
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Halushka M.K.; Fan J.-B.; Bentley K.; Hsie L.; Shen N.; Weder A.; Cooper R.; Lipshutz R.; Chakravarti A.;
Nat. Genet. 22:239-247(1999)
Cited for: VARIANTS TRP-460 AND CYS-586;
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