Variant position: 29 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 465 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VVHELPACTLCAGPLEDAVT IPCGHTFCRLCLPALSQMGAQ
Rhesus macaque VVHELPACTLCVGPLEDAVT APCGHTFCRLCLPTLSQMGAQ
Chimpanzee VVHELPACTLCAGPLEDAVT VPCGHTFCRLCLPALSQMGAQ
Pig --HKGAVCSDCQGRLEDAVT AACGHTFCRLCLPLPPQMGAQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 465 Tripartite motif-containing protein 15
16 – 61 RING-type
The tripartite motif family identifies cell compartments.
Reymond A.; Meroni G.; Fantozzi A.; Merla G.; Cairo S.; Luzi L.; Riganelli D.; Zanaria E.; Messali S.; Cainarca S.; Guffanti A.; Minucci S.; Pelicci P.G.; Ballabio A.;
EMBO J. 20:2140-2151(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANT VAL-29;
Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection.
Goei V.L.; Parimoo S.; Capossela A.; Chu T.W.; Gruen J.R.;
Am. J. Hum. Genet. 54:244-251(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT VAL-29;
Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions.
Shiina T.; Ota M.; Katsuyama Y.; Hashimoto N.; Inoko H.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANT VAL-29;
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