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UniProtKB/Swiss-Prot Q8N0Y7: Variant p.Arg90Gln

Probable phosphoglycerate mutase 4
Gene: PGAM4
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Variant information Variant position: help 90
Type of variant: help LB/B
Residue change: help From Arginine (R) to Glutamine (Q) at position 90 (R90Q, p.Arg90Gln).
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (Q)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 90
Protein sequence length: help 254
Location on the sequence: help VLDAIDQMWLPVVRTWRLNE R HYGGLTGLNKAETAAKHGEA
Residue conservation: help
Human                         VLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEA

Chimpanzee                    VLDAIDQMWLPVVRTWRLNERHYGGLTALNKAETAAKHGEA

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 254 Probable phosphoglycerate mutase 4
Active site 89 – 89 Proton donor/acceptor
Binding site 89 – 92
Binding site 100 – 100
Modified residue 106 – 106 N6-acetyllysine



Literature citations
Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene.
Betran E.; Wang W.; Jin L.; Long M.;
Mol. Biol. Evol. 19:654-663(2002)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS CYS-40; GLN-90 AND THR-175;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.