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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O00222: Variant p.Val548Gly

Metabotropic glutamate receptor 8
Gene: GRM8
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Variant information Variant position: help 548
Type of variant: help LB/B
Residue change: help From Valine (V) to Glycine (G) at position 548 (V548G, p.Val548Gly).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to glycine (G)
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 548
Protein sequence length: help 908
Location on the sequence: help TVKGVPCCWHCERCEGYNYQ V DELSCELCPLDQRPNMNRTG
Residue conservation: help 
Human                         TVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTG

Mouse                         TVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTG

Rat                           TVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 34 – 908 Metabotropic glutamate receptor 8
Topological domain 34 – 583 Extracellular
Glycosylation 565 – 565 N-linked (GlcNAc...) asparagine
Disulfide bond 541 – 553
Alternative sequence 502 – 908 Missing. In isoform C.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.