Variant position: 114 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NDGVEDLRCKYISLIYTNYE AGKDDYVKA-LPGQLKPFETLL
Rhesus macaque NDGVEDLRCKYLSLIYTNYE AGKDDYVKA-LPGQLKPFETL
Mouse NDGVEDLRGKYVTLIYTNYE NGKNDYVKA-LPGHLKPFETL
Rat NDGVEDLRCKYGTLIYTNYE NGKDDYVKA-LPGHLKPFETL
Pig NDGVEDLRCKYATLIYTNYE AGKEKYVKE-LPEHLKPFETL
Bovine NDGVEDLRCKYVSLIYTNYE AGKEDYVKA-LPQHLKPFETL
Goat NDGVEDLRCKYVSLIYTNYQ AGKEDYVKA-LPQHLKPFETL
Xenopus laevis NDGVEDLRQKYGRLIFFEYE TGKDKYLKE-LPSQLDFFERI
Caenorhabditis elegans YEGLRDLHTKYTTMIYRNYE DGKAPYIKDVLPGELARLEKL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 210 Glutathione S-transferase P
83 – 204 GST C-terminal
103 – 103 N6-succinyllysine
116 – 116 N6-succinyllysine
128 – 128 N6-acetyllysine
99 – 99 D -> A. Reduces affinity for glutathione. Slightly reduced catalytic activity.
112 – 135
Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.
Ali-Osman F.; Akande O.; Antoun G.; Mao J.X.; Buolamwini J.;
J. Biol. Chem. 272:10004-10012(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS VAL-105 AND VAL-114;
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-105 AND VAL-114;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.