Variant position: 85 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 275 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HPQWVLTAAHCVGPDVKDLA ALRVQLREQHLYYQDQLLPVS
Mouse HPQWVLTAAHCVGPDVADPN KVRVQLRKQYLYYHDHLMTVS
Rat HPQWVLTAAHCVGPNKADPN KLRVQLRKQYLYYHDHLLTVS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
31 – 275 Tryptase alpha/beta-1
31 – 272 Peptidase S1
74 – 74 Charge relay system
79 – 87 Missing. In isoform 2.
83 – 85
Cloning and characterization of complementary DNA for human tryptase.
Miller J.S.; Westin E.H.; Schwartz L.B.;
J. Clin. Invest. 84:1188-1195(1989)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS THR-85; SER-215; GLN-216 AND LYS-221;
Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson N.E.; Wang H.W.; Bryant K.J.; McNeil H.P.; Husain A.; Liu K.; Tedla N.; Thomas P.S.; King G.C.; Hettiaratchi A.; Cairns J.; Hunt J.E.;
J. Biol. Chem. 283:34178-34187(2008)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); NUCLEOTIDE SEQUENCE [MRNA] OF 16-275 (ALLELE ALPHA; ISOFORM 2); NUCLEOTIDE SEQUENCE [MRNA] OF 54-275 (ALLELE BETA-I; ISOFORM 2); VARIANTS PRO-15 AND THR-85; FUNCTION; FIBRONECTIN CLEAVAGE; TISSUE SPECIFICITY;
Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.
Guida M.; Riedy M.; Lee D.; Hall J.;
Cited for: VARIANTS PRO-15; VAL-18; VAL-23; THR-85; LYS-132; ALA-141; ASN-162; SER-170; SER-215; GLN-216; LYS-221 AND ASN-263;
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