Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P15538: Variant p.Tyr439His

Cytochrome P450 11B1, mitochondrial
Gene: CYP11B1
Feedback?
Variant information Variant position: help 439
Type of variant: help LB/B
Residue change: help From Tyrosine (Y) to Histidine (H) at position 439 (Y439H, p.Tyr439His).
Physico-chemical properties: help Change from large size and aromatic (Y) to medium size and polar (H)
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 439
Protein sequence length: help 503
Location on the sequence: help RPERYNPQRWLDIRGSGRNF Y HVPFGFGMRQCLGRRLAEAE
Residue conservation: help 
Human                         RPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE

Rat                           RPERYMPQRWLERKRS---FQHLAFGFGVRQCLGRRLAEVE

Pig                           RPERYHPQRWLDNQGSGTRFPHLAFGFGMRQCLGRRLAQVE

Bovine                        RPESYHPQRWLDRQGSGSRFPHLAFGFGVRQCLGRRVAEVE

Sheep                         RPESYHPQRWLDRQGSGSRFPHLAFGFGMRQCLGRRVAEVE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 25 – 503 Cytochrome P450 11B1, mitochondrial
Binding site 450 – 450 axial binding residue
Alternative sequence 401 – 466 Missing. In isoform 2.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.