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UniProtKB/Swiss-Prot P43115: Variant p.Pro375Leu

Prostaglandin E2 receptor EP3 subtype
Gene: PTGER3
Variant information

Variant position:  375
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Proline (P) to Leucine (L) at position 375 (P375L, p.Pro375Leu).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are medium size and hydrophobic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  375
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  390
The length of the canonical sequence.

Location on the sequence:   RKFCQIRYHTNNYASSSTSL  P CQCSSTLMWSDHLER
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         RKFCQIRYHTNN--------Y----------------------ASSSTSLPCQCSSTLMWSDHLER-----

Mouse                         RKFCQIRDHTNY------------------------

Rat                           RKFCQIRDHTNY------------------------

Pig                           QKFCQAVSQKQR--------EEAATLIF--------

Bovine                        QKFCQLLKGHSYGLDTEGGTENKDKEMKENLYISNL

Rabbit                        RKFCQVIHENN---------EQKDEIQRENRNVSHS

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 390 Prostaglandin E2 receptor EP3 subtype
Topological domain 350 – 390 Cytoplasmic
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQVILLPQPPK. In isoform 12.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAEEFWGN. In isoform EP3-III.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEEFWGN. In isoform EP3-IV.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS. In isoform EP3-V.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> EEFWGN. In isoform EP3B.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEA. In isoform EP3C.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQEEFWGN. In isoform EP3D.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQLICSLQNSQIQRATAHCGQVQTYRVLNREEMEVLVSSINVYTRISTVKTE. In isoform EP3E.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQLICSLRTLRYRGQLHIVGKYKPIVC. In isoform EP3E2.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQAPLLPTPTVIDPSRFCAQPFRWFLDLSFPAMSSSHPQLPLTLASFKLLREPCSVQLS. In isoform EP3F.
Alternative sequence 360 – 390 IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> EMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS. In isoform EP3G.


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.