Variant position: 458 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1609 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TEAGCRPCSCDPSGS---IDECN IETGRCVCKDNVEGFNCERCK
Mouse TEAGCRPCSCDLRGS---TDECN VETGRCVCKDNVEGFNCE
Xenopus tropicalis TEAGCRPCACNPAGS---TDECN VETGRCSCKDNVEGFNCE
Zebrafish SEAGCRPCSCNPAGS---TQECD VQTGRCQCKENVDGFNCD
Drosophila GPHGCQQCGCDSGGSHQNTPACD TETGICFCKENVEGRRCN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains.
Pikkarainen T.; Kallunki T.; Tryggvason K.;
J. Biol. Chem. 263:6751-6758(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS VAL-458 AND PRO-888;
Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene.
Kallunki T.; Ikonen J.; Chow L.T.; Kallunki P.; Tryggvason K.;
J. Biol. Chem. 266:221-228(1991)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-458 AND PRO-888;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.