Variant position: 86 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 967 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DQSKAWNRYRLPNTLKPDSY RVTLRPYLTPNDRGLYVFKGS
Mouse DESKPWNQYRLPKTLIPDSY RVILRPYLTPNNQGLYIFQGN
Rat DESKPWNQYRLPKTLIPDSY QVTLRPYLTPNEQGLYIFKGS
Pig DQSKPWNRYRLPTTLLPDSY NVTLRPYLTPNADGLYIFKGK
Bovine DQSKPWNRYRLPTTLLPDSY RVTLRPYLTPNNNGLYIFTGS
Rabbit DQNLPWNRYRLPKTLIPDSY NVVLRPYLSPNSQGLYIFTGS
Cat DQSKPWNVYRLPKTLIPDSY NVTLRPYLTPNNKGLYVFTGT
Chicken APNNPWNRWRLPTALKPESY EVTLQPFLTPDDNNMYIFKGN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA.
Olsen J.; Cowell G.M.; Koenigshoefer E.; Danielsen E.M.; Moeller J.; Laustsen L.; Hansen O.C.; Welinder K.G.; Engberg J.; Hunziker W.; Spiess M.; Sjoestroem H.; Noren O.;
FEBS Lett. 238:307-314(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS GLN-86 AND MET-603;
Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
Look A.T.; Ashmun R.A.; Shapiro L.H.; Peiper S.C.;
J. Clin. Invest. 83:1299-1307(1989)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PROTEIN SEQUENCE OF 2-21; VARIANT GLN-86; SUBCELLULAR LOCATION;
Genomic organisation of aminopeptidase N.
Eiz-Vesper B.; Fuchs N.; Gottschalk D.; Mueller K.; Reuter S.; Blasczyk R.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-479 AND 524-967; VARIANT GLN-86;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.