Variant position: 322 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 351 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EQEALTGECKELEKKNEALK ERADSLAKEIQYLKDLIEEVR
Mouse EQEALTGECKELEKKNEALK EKADSLAKEIQYLKDLIEEVR
Rat EQEALTGECKELEKKNEALK EKADSLAKEIQYLKDLIEEVR
Bovine EQEALTGECKELEKKNEALK EKADSLAKEIQYLKDQIEEVR
Zebrafish EQESLNSECSELEKKNRELS EKADSLSREIQYLRDLLEEMR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 351 Cyclic AMP-dependent transcription factor ATF-4
278 – 341 bZIP
305 – 341 Interaction with GABBR1
306 – 334 Leucine-zipper
280 – 340
311 – 311 N6-acetyllysine
311 – 311 K -> R. Decreased acetylation without affecting ubiquitination by SCF(BTRC).
288 – 340
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.