Sequence information
Variant position: 322 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 351 The length of the canonical sequence.
Location on the sequence:
EQEALTGECKELEKKNEALK
E RADSLAKEIQYLKDLIEEVR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EQEALTGECKELEKKNEALKE RADSLAKEIQYLKDLIEEVR
Mouse EQEALTGECKELEKKNEALKE KADSLAKEIQYLKDLIEEVR
Rat EQEALTGECKELEKKNEALKE KADSLAKEIQYLKDLIEEVR
Bovine EQEALTGECKELEKKNEALKE KADSLAKEIQYLKDQIEEVR
Zebrafish EQESLNSECSELEKKNRELSE KADSLSREIQYLRDLLEEMR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 351
Cyclic AMP-dependent transcription factor ATF-4
Domain
278 – 341
bZIP
Region
305 – 341
Interaction with GABBR1
Region
306 – 334
Leucine-zipper
Coiled coil
280 – 340
Modified residue
311 – 311
N6-acetyllysine
Mutagenesis
311 – 311
K -> R. Decreased acetylation without affecting ubiquitination by SCF(BTRC).
Helix
288 – 340
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.