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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q92889: Variant p.Ser662Pro

DNA repair endonuclease XPF
Gene: ERCC4
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Variant information Variant position: help 662
Type of variant: help LB/B
Residue change: help From Serine (S) to Proline (P) at position 662 (S662P, p.Ser662Pro).
Physico-chemical properties: help Change from small size and polar (S) to medium size and hydrophobic (P)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 662
Protein sequence length: help 916
Location on the sequence: help VPEEREGRDETNLDLVRGTA S ADVSTDTRKAGGQEQNGTQQ
Residue conservation: help 
Human                         VPEEREGR----DETNLDLVRGTASADVSTD----TRKAGG---------QEQNGTQQ

Mouse                         VPEEREGR----DETNLDLARGSAALDAPTD----TRKAGG

Drosophila                    IPKYQDGK----TDEAFLLLK--TYDDEPTDENAKSRQAGG

Slime mold                    IDTEQEGKIQLVDNSKLELL-----DDMKST---RNSRLGG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 916 DNA repair endonuclease XPF
Region 658 – 813 Nuclease
Region 660 – 679 Disordered
Alternative sequence 373 – 916 Missing. In isoform 2.



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-168; SER-379; GLN-415; PRO-662; THR-706; VAL-873 AND GLY-875;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.