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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P18887: Variant p.Arg560Trp

DNA repair protein XRCC1
Gene: XRCC1
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Variant information Variant position: help 560
Type of variant: help LB/B
Residue change: help From Arginine (R) to Tryptophan (W) at position 560 (R560W, p.Arg560Trp).
Physico-chemical properties: help Change from large size and basic (R) to large size and aromatic (W)
BLOSUM score: help -3
Polymorphism: help Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.
Other resources: help


Sequence information Variant position: help 560
Protein sequence length: help 633
Location on the sequence: help PDFFQGKHFFLYGEFPGDER R KLIRYVTAFNGELEDYMSDR
Residue conservation: help 
Human                         PDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDYMSDR

Mouse                         PDFFEGKHFFLYGEFPGDERRRLIRYVTAFNGELEDYMNER

Rat                           PDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDYMSDR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 633 DNA repair protein XRCC1
Domain 538 – 629 BRCT 2
Helix 558 – 568



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.