Variant position: 64 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 318 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LYEDPPDQKTSPSGKPATLK ICSWNVDGLRAWIKKKGLDWV
Gorilla LYEDPPDQKTSPSGKPATLK ICSWNVDGLRAWIKKKGLDWV
Chimpanzee LYEDPPDQKTSPSGKPATLK ICSWNVDGLRAWIKKKGLDWV
Mouse LYEDPPDQKTSPSGKSATLK ICSWNVDGLRAWIKKKGLDWV
Rat LYEDPPDQKTSASGKSATLK ICSWNVDGLRAWIKKKGLDWV
Bovine LYEDPPDQKTSPSGKSATLK ICSWNVDGLRAWIKKKGLDWV
Zebrafish LYEDPPEKLTSKDGRAANMK ITSWNVDGLRAWVKKNGLDWV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 318 DNA-(apurinic or apyrimidinic site) lyase
32 – 318 DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
64 – 80 Nuclear export signal (NES)
70 – 70 Magnesium 1
54 – 54 Phosphoserine
65 – 65 S-nitrosocysteine; alternate
65 – 65 C -> A. Abolishes the redox activity. Does not abolish the AP endodeoxyribonuclease and phosphodiesterase activities. Reduces protection from granzyme A-mediated cell death; when associated with A-31 and A-210.
65 – 65 C -> S. Does not abolish NO-induced nitrosylation. Enhances NO-induced nuclear export.
68 – 68 N -> A. Nearly abolishes AP endodeoxyribonuclease activity.
70 – 70 D -> A. Strongly reduces AP endodeoxyribonuclease activity.
62 – 68
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS HIS-51; VAL-64 AND GLU-148;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.