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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P32455: Variant p.Thr349Ser

Guanylate-binding protein 1
Gene: GBP1
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Variant information Variant position: help 349
Type of variant: help LB/B
Residue change: help From Threonine (T) to Serine (S) at position 349 (T349S, p.Thr349Ser).
Physico-chemical properties: help Change from medium size and polar (T) to small size and polar (S)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 349
Protein sequence length: help 592
Location on the sequence: help QKAIAHYEQQMGQKVQLPTE T LQELLDLHRDSEREAIEVFI
Residue conservation: help 
Human                         QKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFI

Mouse                         QKAITYYEEQMNQKIHMPTETLQELLDLHRTCEREAIEVFM
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 589 Guanylate-binding protein 1



Literature citations
Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.
Cheng Y.-S.E.; Patterson C.E.; Staeheli P.;
Mol. Cell. Biol. 11:4717-4725(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS SER-349 AND GLY-409; Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N.; Chen X.; Rolfs A.; Halleck A.; Hines L.; Eisenstein S.; Koundinya M.; Raphael J.; Moreira D.; Kelley T.; LaBaer J.; Lin Y.; Phelan M.; Farmer A.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS SER-349 AND GLY-409; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS SER-349 AND GLY-409;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.