Variant position: 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 336 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SVLGILASSTVLFMLFRPLF RWQLCPGWPVLAQLAVGSALF
Gorilla SVLGILASSTVLFILFRPLF RWQLCPGWPVLAQLAVGSALF
Rhesus macaque SVLGILASGTVLFMFFRPLF HWQLCPGWPVLAQLAVGSALF
Chimpanzee SVLGILASSTVLFMLFRPLF RWQLCPGWPVLAQLAVGSALF
Mouse SVLGMLASGSILFAILRPFF HWQICPSWPILAELAVGSALF
Bovine SILGILASGTILYALLRPLF RWQLYQDRSTLVQLAVGSALF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 336 Atypical chemokine receptor 1
85 – 95 Cytoplasmic
51 – 276
Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.
Tournamille C.; Le Van Kim C.; Gane P.; Le Pennec P.Y.; Roubinet F.; Babinet J.; Cartron J.-P.; Colin Y.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2); VARIANTS ASP-42; CYS-89 AND THR-100;
The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.
Olsson M.L.; Smythe J.S.; Hansson C.; Poole J.; Mallinson G.; Jones J.; Avent N.D.; Daniels G.;
Br. J. Haematol. 103:1184-1191(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS ASP-42; CYS-89 AND THR-100;
A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.
Parasol N.; Reid M.; Rios M.; Castilho L.; Harari I.; Kosower N.S.;
Cited for: VARIANT CYS-89;
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