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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P58012: Variant p.Gly187Asp

Forkhead box protein L2
Gene: FOXL2
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Variant information Variant position: help 187 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Glycine (G) to Aspartate (D) at position 187 (G187D, p.Gly187Asp). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to medium size and acidic (D) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In POF3; does not affect nuclear localization; reduces transcriptional activation of OSR2. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 187 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 376 The length of the canonical sequence.
Location on the sequence: help FGAGGAAGGCGVAGAGADGY G YLAPPKYLQSGFLNNSWPLP The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         FGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLP

Mouse                         FGSGGAAGGCGVPGAGADGYGYLAPPKYLQSGFLNNSWPLP

Pig                           FGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLP

Bovine                        FGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLP

Rabbit                        FGAAGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLP

Goat                          FGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLP
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 376 Forkhead box protein L2



Literature citations
Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2.
Laissue P.; Lakhal B.; Benayoun B.A.; Dipietromaria A.; Braham R.; Elghezal H.; Philibert P.; Saad A.; Sultan C.; Fellous M.; Veitia R.A.;
J. Med. Genet. 46:455-457(2009)
Cited for: FUNCTION AS TRANSCRIPTIONAL ACTIVATOR OF OSR2; VARIANT POF3 ASP-187; CHARACTERIZATION OF VARIANT POF3 ASP-187; FOXL2 mutation screening in a large panel of POF patients and XX males.
De Baere E.; Lemercier B.; Christin-Maitre S.; Durval D.; Messiaen L.; Fellous M.; Veitia R.;
J. Med. Genet. 39:E43-E43(2002)
Cited for: VARIANTS ASP-187 AND SER-285;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.