Variant position: 116 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 164 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GRCAAFGVCCNDESCVTEPE CREG--FHRRARASDRSNATQLD
Mouse GRCAAVGICCSDESCVAEPE CHDG--FFRLTRAREPSNATQ
Rat GRCAAAGICCSDESCVAEPE CREG--FFRLTRAREQSNATQ
Pig GRCAAAGICCNDESCVTEPE CREGASFLRRARASDRSNATL
Bovine GRCAAAGICCNDESCVTEPE CREGVGFPRRVRANDRSNATL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
32 – 124 Neurophysin 2
131 – 131 N-linked (GlcNAc...) asparagine
98 – 116
Identification of two distinct mutations at the same nucleotide position, concomitantly with a novel polymorphism in the vasopressin-neurophysin II gene (AVP-NP II) in two Dutch families with familial neurohypophyseal diabetes insipidus.
Abbes A.P.; Bruggeman B.; van den Akker E.L.T.; de Groot M.R.; Franken A.A.M.; Drexhage V.R.; Engel H.;
Clin. Chem. 46:1699-1702(2000)
Cited for: VARIANTS NDI ARG-116 AND GLY-116;
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