Variant position: 173 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 745 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SKSSGCAYQDVGVTCPEQDK YRTITGMCNNRRSPTLGASNR
Mouse SVSSGCAYQDVRVTCPPNDK YRTITGHCNNRRSPTLGASNR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
49 – 745 89 kDa myeloperoxidase
155 – 745 84 kDa myeloperoxidase
165 – 745 Myeloperoxidase
165 – 278 Myeloperoxidase light chain
167 – 180
182 – 182 N -> NRCGWLGVAAGTGLREASRTPQASRCQRPVLPC. In isoform H7.
A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation.
DeLeo F.R.; Goedken M.; McCormick S.J.; Nauseef W.M.;
J. Clin. Invest. 101:2900-2909(1998)
Cited for: VARIANT MPOD CYS-173; CHARACTERIZATION OF VARIANT MPOD CYS-173;
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