Variant position: 162 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 410 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMTIKLWDFQ-GF
Chimpanzee FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMT
Mouse FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMT
Rat FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMT
Pig FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMT
Bovine FERTLKGHTDSVEDIS-----FDHS GK----LLASCSADMT
Cat FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMT
Chicken FERTLKGHTDSVQDIS-----FDHT GK----LLASCSADMT
Xenopus laevis FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMT
Xenopus tropicalis FERTLKGHTDSVQDIS-----FDHS GK----LLASCSADMT
Caenorhabditis elegans LERTLKGHTDAVNDIA-----IDAA GK----QLVSCSSDLS
Drosophila YERSLKGHTDSVQDVA-----FDAQ GK----LLASCSADLS
Slime mold FERTLKGHTNAVQDID-----FDKT GN----LLASCSADLT
Baker's yeast PLASLQSHTKAITSMDVLFTNYTNS SKKNYLVIVTASKDLQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 410 Platelet-activating factor acetylhydrolase IB subunit alpha
148 – 187 WD 2
83 – 410 Interaction with dynein and dynactin
134 – 170 Missing. In isoform 2.
LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ.
Leventer R.J.; Cardoso C.; Ledbetter D.H.; Dobyns W.B.;
Cited for: VARIANTS LIS1 SER-31; SER-162 AND HIS-317;
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