Variant position: 28 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 416 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LLRRCRLRLVEELQVDQLWD ALLSRELFRPHMIEDIQRAGS
Mouse LLRRCRVRLVSELQVAELWD ALLSRELFTRDMIEDIQQAGS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 92 CARD
1 – 83 Missing. In isoform 4.
26 – 31
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Duan H.; Orth K.; Chinnaiyan A.M.; Poirier G.G.; Froelich C.J.; He W.-W.; Dixit V.M.;
J. Biol. Chem. 271:16720-16724(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS VAL-28 AND ARG-221;
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis.
Seol D.W.; Billiar T.R.;
J. Biol. Chem. 274:2072-2076(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT VAL-28;
Cloning of a novel human caspase-9 splice variant containing only the CARD domain.
Wang P.; Shi T.; Ma D.;
Life Sci. 79:934-940(2006)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); VARIANT VAL-28;
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-28; LEU-99; ILE-102; VAL-106; ASP-114; HIS-173 AND ARG-221;
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