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UniProtKB/Swiss-Prot O15169: Variant p.Pro345Leu

Axin-1
Gene: AXIN1
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Variant information Variant position: help 345
Type of variant: help US
Residue change: help From Proline (P) to Leucine (L) at position 345 (P345L, p.Pro345Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help -3
Variant description: help In HCC; uncertain significance; somatic mutation.
Other resources: help


Sequence information Variant position: help 345
Protein sequence length: help 862
Location on the sequence: help SLSSDADTLSLTDSSVDGIP P YRIRKQHRREMQESVQVNGR
Residue conservation: help 
Human                         SLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGR

Mouse                         SLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESIQVNGR

Rat                           SLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGR

Chicken                       SMSSDADTMSLTDSSIDGIPPYRLRKQHRREMQESAKANGR

Xenopus laevis                SMSSDADTMSLTDSSVDGIPPYRLRKHYRREMQESANANGR

Zebrafish                     SMSSDADTLSLTDSSVDGVPPYRYRKPHRREIHESAKVNGR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 862 Axin-1



Literature citations
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
Taniguchi K.; Roberts L.R.; Aderca I.N.; Dong X.; Qian C.; Murphy L.M.; Nagorney D.M.; Burgart L.J.; Roche P.C.; Smith D.I.; Ross J.A.; Liu W.;
Oncogene 21:4863-4871(2002)
Cited for: INVOLVEMENT IN HCC; VARIANTS HCC ARG-106; LEU-345 AND SER-425; VARIANTS SER-650 AND GLN-841;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.