Variant position: 425 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 862 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AEEKLEERLKRVRMEEEGED GDPSSGPPGPCHKLPPAPAWH
Mouse AEEKLEERLKRVRMEEEGED GEMPSGP-MASHKLPSVPAWH
Rat AEEKLEERLKRVRMEEEGED GEMPSGP-MASHKLPSVPAWH
Chicken AEEKLEERLKRVRAEEEGED ADISSGPSVISHKMPSAQPFH
Xenopus laevis AEQKLEERLKRVRAEEEGDD GDVSSGPSVISHKLPSGPPMH
Zebrafish AQEKLEERLKRVRLEEEGDD ADISTGPSLANHRVPPAVHVQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
Taniguchi K.; Roberts L.R.; Aderca I.N.; Dong X.; Qian C.; Murphy L.M.; Nagorney D.M.; Burgart L.J.; Roche P.C.; Smith D.I.; Ross J.A.; Liu W.;
Cited for: VARIANTS HCC ARG-106; LEU-345; SER-425 AND SER-650; VARIANT HEPATOBLASTOMA GLN-841;
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