Variant position: 841 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 862 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RYYFKKVSDEFDCGVVFEEV REDEAVLPVFEEKIIGKVEKV
Mouse RYYFKKVSDEFDCGVVFEEV REDEAVLPVFEEKIIGKVEKV
Rat RYYFKKVSDEFDCGVVFEEV REDEAILPVFEEKIIGKVEKV
Chicken RYYFKKVSDEFDCGVVFEEV REDDTILPIFEEKIIGKVEKI
Xenopus laevis RYYFKKVSDEFDCGVVFEEV REDDMILPIYEEKIIGQVEKI
Zebrafish KYYFKKVSYEFDCGVVFEEV REDDAILPIFEEKIIGKVEKV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 862 Axin-1
780 – 862 DIX
857 – 857 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
860 – 860 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.
Taniguchi K.; Roberts L.R.; Aderca I.N.; Dong X.; Qian C.; Murphy L.M.; Nagorney D.M.; Burgart L.J.; Roche P.C.; Smith D.I.; Ross J.A.; Liu W.;
Cited for: VARIANTS HCC ARG-106; LEU-345; SER-425 AND SER-650; VARIANT HEPATOBLASTOMA GLN-841;
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