Variant position: 259 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1085 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KEK------LIRGESEFSFEELRAQK----- YNQRRKHEQWVNEDRHYMKRK
Mouse KEK------LIRGDSEFSFEELRAQK----- YNQRKKHEQW
Caenorhabditis elegans EEF------RFAKWKDTFGEDVDDDY----- RKRKDSGVVF
Slime mold DEKGGSTTNEVLTDSKFFGSSRKAAALMAAG QTQQTSQMKW
Baker's yeast NQR------LKNGNKKTS------IY----- ADQKQSNNPV
Fission yeast ------------------------LE----- SEANTPNLPL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1085 Mitotic checkpoint serine/threonine-protein kinase BUB1
Bub1 regulates chromosome segregation in a kinetochore-independent manner.
Klebig C.; Korinth D.; Meraldi P.;
J. Cell Biol. 185:841-858(2009)
Cited for: FUNCTION; MUTAGENESIS OF ALA-130; CHARACTERIZATION OF VARIANTS CYS-259 AND ASN-265;
A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T.
Hempen P.M.; Kurpad H.; Calhoun E.S.; Abraham S.; Kern S.E.;
Hum. Mutat. 21:445-445(2003)
Cited for: VARIANTS PANCREATIC CANCER CYS-259 AND ASN-265;
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