Variant position: 1580 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2725 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VEFTIDARDAGEGLLTVQIL DPEGKPKKANIRDNGDGTYTV
Mouse VEFTIDARDAGQGLLTVQIL DPEGKPKKANIRDNGDGTYTV
Rat VEFTIDARDAGEGLLTVQIL DPEGKPKKANIRDNGDGTYTV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Molecular cloning of human ABPL, an actin-binding protein homologue.
Xie Z.-W.; Xu W.-F.; Davie E.W.; Chung D.W.;
Biochem. Biophys. Res. Commun. 251:914-919(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANTS GLY-1580; ALA-1599 AND PRO-2203;
Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation.
van der Ven P.F.M.; Obermann W.M.J.; Lemke B.; Gautel M.; Weber K.; Fuerst D.O.;
Cell Motil. Cytoskeleton 45:149-162(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANTS GLY-1580; ALA-1599; ARG-2135 AND PRO-2203;
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