Variant position: 526 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 567 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NHQGIQMVCETLTECWDHDP EARLTAQCVAERFSELEHLDR
Mouse NHQGIQIVCETLTECWDHDP EARLTAQCVAERFSELEHPER
Rat NHQGIQIVCETLTECWDHDP EARLTAQCVAERFSELEHPDR
Chicken NHQGIQMVCETLIECWDHDP EARLTAQCVAERFSEFKHHDK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
Tanaka S.; Mori M.; Mafune K.; Ohno S.; Sugimachi K.;
Br. J. Cancer 82:1557-1560(2000)
Cited for: VARIANT ESOPHAGEAL CANCER GLN-526;
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