Variant position: 15 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 178 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MHSSALLC-CLVLLT GVRASPGQGTQSENSCTHFPG
Rhesus macaque MHSSALLC-CLVLLT GVRASPGQGTQSENSCTRFP
Chimpanzee MHSSALLC-CLVLLT GVRASPGQGTQSENSCTHFP
Mouse MPGSALLC-CLLLLT GMRISRGQYSREDNNCTHFP
Rat MPGSALLC-CLLLLA GVKTSKGHSIRGDNNCTHFP
Pig MPSSALLY-CLIFLA GVAAS----IKSENSCIHFP
Bovine MHSSALLC-CLVFLA GVAASRDASTLSDSSCIHLP
Rabbit MLSSALLC-CLVFLG GTGASRGQDTPAENSCIHFP
Sheep PSSSAVLC-CLVFLA GVAASRDASTLSDSSCTHFP
Cat MHSSALLC-FLVFLA GVGASRHQSTLSEDNCTHFS
Horse MHSSALLC-YLVFLA GVGASRDRGTQSENSCTHFP
Chicken ----MQTC-CQALLL LLAACTLPAHCLEPTCLHFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 18
A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease.
van der Linde K.; Boor P.P.; Sandkuijl L.A.; Meijssen M.A.; Savelkoul H.F.; Wilson J.H.; de Rooij F.W.;
Scand. J. Gastroenterol. 38:611-617(2003)
Cited for: VARIANT ARG-15;
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