Variant position: 167 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1382 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EKNNELCYLATIDWSRILDS VEDNYIVLNKDDNE--ECGDI-CP----
Mouse EKNNELCYLATIDWSRILDS VEDNYIVLNKDDNE--ECGDV
Rat EKNNELCYLATIDWSRILDY VEDNYIVLNKDDNE--ECGDV
Xenopus laevis EKNNELCYLSTIDWSIILDS VEDNYIELNRDNKE--ECGDV
Caenorhabditis elegans IDNRKLCYTKTIDWKHLITS SINDVVVDNAAEYAVTETGLM
Drosophila EKNHKLCYDRTIDWLEILAE NETQLVVLTENGKE-KECRLS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 758 Insulin receptor subunit alpha
28 – 758 Extracellular
28 – 174 Leu-rich
153 – 182
Identification of three novel mutations in the insulin receptor gene in type A insulin resistant patients.
Rique S.; Nogues C.; Ibanez L.; Marcos M.V.; Ferragut J.; Carrascosa A.; Potau N.;
Clin. Genet. 57:67-69(2000)
Cited for: VARIANTS IRAN TYPE A LEU-167 AND VAL-1055;
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