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UniProtKB/Swiss-Prot P06213: Variant p.Gln492Lys

Insulin receptor
Gene: INSR
Variant information

Variant position:  492
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Glutamine (Q) to Lysine (K) at position 492 (Q492K, p.Gln492Lys).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and polar (Q) to large size and basic (K)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page



Sequence information

Variant position:  492
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  1382
The length of the canonical sequence.

Location on the sequence:   VSGTKGRQERNDIALKTNGD  Q ASCENELLKFSYIRTSFDKI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         VSGTKGRQ-ERNDIALKTNGDQASCENELLKFSYIRTSFDKI

Mouse                         VSGTKGRQ-ERNDIALKTNGDQASCENELLKFSFIRTSFDK

Rat                           VSGTKGRQ-ERNDIALKTNGDQASCENELLKFSFIRTSFDK

Xenopus laevis                VTGTKGRQ-DKNDIATKTNGDQASCEDNLLTFNFIKTSHDM

Caenorhabditis elegans        KLNIPLDPIDQSE---GTNGEKAICEDMAINVSITAVNADS

Drosophila                    MLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANS

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 28 – 758 Insulin receptor subunit alpha
Topological domain 28 – 758 Extracellular
Disulfide bond 462 – 495


Literature citations

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
Ebina Y.; Ellis L.; Jarnagin K.; Edery M.; Graf L.; Clauser E.; Ou J.-H.; Masiarz F.; Kan Y.W.; Goldfine I.D.; Roth R.A.; Rutter W.J.;
Cell 40:747-758(1985)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG); VARIANTS GLY-2; HIS-171; THR-448 AND LYS-492;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.