Variant position: 1095 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1382 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ASVMKGFTCHHVVRLLGVVS KGQPTLVVMELMAHGDLKSYL
Mouse ASVMKGFTCHHVVRLLGVVS KGQPTLVVMELMAHGDLKSHL
Rat ASVMKGFTCHHVVRLLGVVS KGQPTLVVMELMAHGDLKSHL
Xenopus laevis ASVMKAFNCHHVVRLLGVVS KGQPTLVIMELMAHGDLKSYL
Caenorhabditis elegans ANIMKNFKTNFIVKLYGVIS TVQPAMVVMEMMDLGNLRDYL
Drosophila ASVMKEFDTYHVVRLLGVCS RGQPALVVMELMKKGDLKSYL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms.
O'Rahilly S.; Choi W.H.; Patel P.; Turner R.C.; Flier J.S.; Moller D.E.;
Cited for: VARIANT GLU-1095;
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