Variant position: 923 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 966 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GPPVTAQPIISEDQTAALMA HLFEMGFCDRQLNLRLLKKHN
Mouse GPPVTAQPIVSEDQTTALMA HLFEMGFCDRQLNLRLLRKHN
Rat GPPVTAQPVISEDQTAALMA HLFEMGFCDRQLNLRLLRKHN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 966 Next to BRCA1 gene 1 protein
913 – 957 UBA
910 – 966 PIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTELLQLNNNDWYSQRY -> GLWGLLSFLHLAKKCFFLKAPSEAFSWF. In isoform 2.
917 – 927
A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1.
Campbell I.G.; Nicolai H.M.; Foulkes W.D.; Senger G.; Stamp G.W.; Allan G.; Boyer C.; Jones K.; Bast R.C. Jr.; Solomon E.; Trowsdale J.; Black D.M.;
Hum. Mol. Genet. 3:589-594(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ARG-923;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANT ARG-923;
Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes.
Dimitrov S.; Brennerova M.; Forejt J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-42; VARIANT ARG-923;
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