Variant position: 307 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 704 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LNGRRMNTLQAIWMMDPKDV REWQHEEFYRYVAQAHDKPRY
Mouse LNGKRINTLQAIWMMDPKDI SEFQHEEFYRYIAQAYDKPRF
Rat LNGRRINTLQAIWMMDPKDI SEFQHEEFYRYIAQAYDKPRF
Bovine LNGRRMNTLQAIWMMDPKDV GEGQHEEFYRYVAQAHDRPRY
Slime mold LNGTTVNTIKPLWTLNKNAI SEEEHKEFYQFLSKSYDTPSY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
60 – 704 Heat shock protein 75 kDa, mitochondrial
324 – 324 N6-acetyllysine
A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses.
Simmons A.D.; Musy M.M.; Lopes C.S.; Hwang L.-Y.; Yang Y.-P.; Lovett M.;
Hum. Mol. Genet. 8:2155-2164(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLY-307;
Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
Song H.Y.; Dunbar J.D.; Zhang Y.X.; Guo D.; Donner D.B.;
J. Biol. Chem. 270:3574-3581(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-704; VARIANT GLY-307;
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