Variant position: 164 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 781 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QNLQNQQIFSVAPGSDSSNG TVSSVQYQVIPQIQSADGQQV
Mouse QNLQNQQIFSVAPGSDSSNG TVSNVQYQVIPQIQSTDAQQV
Chicken QSLQNQQIFSVAPGSDSSNG TVSNVQYQVIPQIQTADGQQV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 781 Transcription factor Sp3
138 – 237 Transactivation domain (Gln-rich)
1 – 302 Missing. In isoform 4.
1 – 285 Missing. In isoform 3.
AUA as a translation initiation site in vitro for the human transcription factor Sp3.
Hernandez E.M.; Johnson A.; Notario V.; Chen A.; Richert J.R.;
J. Biochem. Mol. Biol. 35:273-282(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5); VARIANT ALA-164;
Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis.
Moran K.M.; Crusio R.H.; Chan C.H.; Grekova M.C.; Richert J.R.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 6); ALTERNATIVE INITIATION (ISOFORMS 2; 3 AND 4); VARIANT ALA-164;
Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.
Hagen G.; Mueller S.; Beato M.; Suske G.;
Nucleic Acids Res. 20:5519-5525(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-781; VARIANT ALA-164;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.