Variant position: 57 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 80 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSQSTSNSGLAPNPTNATTK AAGGALQSTASLFVVSLSLLH
Mouse NQNISA----SPNPSNATTR GGGSSLQSTAGLLALSLSLLH
Rat NQSISA----APNPTNATTR SGCSSLQSTAGLLALSLSLLH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 59 Signal transducer CD24
59 – 59 GPI-anchor amidated glycine
52 – 52 N-linked (GlcNAc...) asparagine
CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas.
Jackson D.; Waibel R.; Weber E.; Bell J.; Stahel R.A.;
Cancer Res. 52:5264-5270(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT VAL-57;
The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21.
Zarn J.A.; Jackson D.G.; Bell M.V.; Jones T.; Weber E.; Sheer D.; Waibel R.; Stahel R.A.;
Cytogenet. Cell Genet. 70:119-125(1995)
Cited for: VARIANT VAL-57; IDENTIFICATION;
CD24 is a genetic modifier for risk and progression of multiple sclerosis.
Zhou Q.; Rammohan K.; Lin S.; Robinson N.; Li O.; Liu X.; Bai X.-F.; Yin L.; Scarberry B.; Du P.; You M.; Guan K.; Zheng P.; Liu Y.;
Proc. Natl. Acad. Sci. U.S.A. 100:15041-15046(2003)
Cited for: VARIANT VAL-57; TISSUE SPECIFICITY; INVOLVEMENT IN SUSCEPTIBILITY TO MS;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.