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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P03952: Variant p.Ser269Cys

Plasma kallikrein
Gene: KLKB1
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Variant information Variant position: help 269
Type of variant: help LB/B
Residue change: help From Serine (S) to Cysteine (C) at position 269 (S269C, p.Ser269Cys).
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (C)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 269
Protein sequence length: help 638
Location on the sequence: help IESQRNVCLLKTSESGTPSS S TPQENTISGYSLLTCKRTLP
Residue conservation: help 
Human                         IESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLP--

Mouse                         TESQRNVCFLKTSKSGRPSPPIPQENAISGYSLLTCRKTRP

Rat                           TESQRNVCFLKTSKSGRPSPPIIQENAVSGYSLFTCRKARP

Bovine                        TDSQRNVCFLKTSQSGSPSSPTPQENAISGYSLLTCKQTLP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 20 – 390 Plasma kallikrein heavy chain
Domain 201 – 284 Apple 3
Disulfide bond 201 – 284



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASN-143; THR-178; GLN-202; CYS-269; VAL-311; ALA-358; ALA-381; PRO-442 AND GLN-560;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.