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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P00747: Variant p.Glu57Lys

Plasminogen
Gene: PLG
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Variant information Variant position: help 57
Type of variant: help LB/B
Residue change: help From Glutamate (E) to Lysine (K) at position 57 (E57K, p.Glu57Lys).
Physico-chemical properties: help Change from medium size and acidic (E) to large size and basic (K)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 57
Protein sequence length: help 810
Location on the sequence: help TKKQLGAGSIEECAAKCEED E EFTCRAFQYHSKEQQCVIMA
Residue conservation: help 
Human                         TKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMA

Rhesus macaque                TKKQLGAGSIEECAAKCEEEEEFTCRSFQYHSKEQQCVIMA

Mouse                         TKKQLAAGGVSDCLAKCEGETDFVCRSFQYHSKEQQCVIMA

Rat                           TKKQLAAGSIADCLAKCEGETDFICRSFQYHSKEQQCVIMA

Pig                           SRKQVAARSVEECAAKCEAETNFICRAFQYHSKDQQCVVMA

Bovine                        SRKNLAGRSVEDCAAKCEEETDFVCRAFQYHSKEQQCVVMA
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 20 – 810 Plasminogen
Chain 20 – 580 Plasmin heavy chain A
Peptide 20 – 97 Activation peptide
Domain 20 – 98 PAN
Disulfide bond 49 – 73
Disulfide bond 53 – 61
Beta strand 57 – 59



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LYS-57; GLN-133; HIS-261; TRP-408; ASN-472; VAL-494 AND TRP-523;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.