Variant position: 472 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 810 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKCSGTEASVVAPPPVVLLP DVETPSEEDCMFGNGKGYRGK
Rhesus macaque KKCSGTEGSVAAPPPVAQLP DAETPSEEDCMFGNGKGYRGK
Mouse KRCSETGGSVVELPTVSQEP SGPSDSETDCMYGNGKDYRGK
Rat KRCSETGGGVAESAIVPQVP SAPGTSETDCMYGNGKEYRGK
Pig KKCSETEQQVTNFPAIAQVP SVEDLS-EDCMFGNGKRYRGK
Bovine KKCSETPEQV---PAAPQAP GVENPPEADCMIGTGKSYRGK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 810 Plasminogen
20 – 580 Plasmin heavy chain A
98 – 580 Plasmin heavy chain A, short form
Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.
Petersen T.E.; Martzen M.R.; Ichinose A.; Davie E.W.;
J. Biol. Chem. 265:6104-6111(1990)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ASN-472;
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LYS-57; GLN-133; HIS-261; TRP-408; ASN-472; VAL-494 AND TRP-523;
Sottrup-Jensen L.; Petersen T.E.; Magnusson S.;
Cited for: PROTEIN SEQUENCE OF 20-810; VARIANT ASN-472;
The primary structure of human plasminogen.
Sottrup-Jensen L.; Claeys H.; Zajdel M.; Petersen T.E.; Magnusson S.;
Cited for: PROTEIN SEQUENCE OF 95-580; 581-626; 657-700 AND 732-810; VARIANT ASN-472;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.