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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q13651: Variant p.Ser420Leu

Interleukin-10 receptor subunit alpha
Gene: IL10RA
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Variant information Variant position: help 420
Type of variant: help LB/B
Residue change: help From Serine (S) to Leucine (L) at position 420 (S420L, p.Ser420Leu).
Physico-chemical properties: help Change from small size and polar (S) to medium size and hydrophobic (L)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 420
Protein sequence length: help 578
Location on the sequence: help DSGIDLVQNSEGRAGDTQGG S ALGHHSPPEPEVPGEEDPAA
Residue conservation: help 
Human                         DSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAA

Mouse                         DSDVNLVQNSPGQPKYTQDASALGHVCLLEPKAPEEKDQVM
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 22 – 578 Interleukin-10 receptor subunit alpha
Topological domain 257 – 578 Cytoplasmic
Region 313 – 436 Disordered



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-61; ILE-113; GLY-159; GLN-212; GLY-351 AND LEU-420;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.