UniProtKB/SwissProt variant VAR

Interleukin-11
Gene: IL11
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Variant information Variant position:

112
Type of variant:

LB/B
Residue change:

From Arginine (R) to Histidine (H) at position 112 (R112H, p.Arg112His).
Physico-chemical properties:

Change from large size and basic (R) to medium size and polar (H)
BLOSUM score:

0
Other resources:

Variant rs4252548 [ dbSNP | Ensembl ]

Sequence information Variant position:

112
Protein sequence length:

199
Location on the sequence:

GVLTRLRADLLSYLRHVQWL R RAGGSSLKTLEPELGTLQAR
Residue conservation:

Human                         GVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQAR

Mouse                         GVLTRLRVDLMSYLRHVQWLRRAGGPSLKTLEPELGALQAR

Rat                           GVLTRLRVDLMSYFRHVQWLRRAAGPSLKTLEPELGALQAR

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	22 – 199	Interleukin-11
Helix	90 – 114

Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS MET-108 AND HIS-112;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P20809: Variant p.Arg112His