Variant position: 215 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 427 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ASSDTIN-------IWFCSLDVSASSR MVVTGDNVGNVILLNMDGKEL
Mouse TSSNSCK-------VWFCSLDVSAKSR VVVTGDNMGHVILL
Bovine ASSDTCN-------VWFCSLDVSVKSR VVVTGDNVGHVILL
Chicken SRAPDCGHENHNVCCWYCSVDVSASCR AVVTGDNLGNVVLL
Xenopus tropicalis TNTEDWA-------MWYCSLDVSAERQ CVVTGDNVGNVVLL
Zebrafish AKTDSWD-------YWYCCVDVSVSRQ MLATGDSTGRLLLL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 427 DNA damage-binding protein 2
203 – 238 WD 3
153 – 341 Missing. In isoform D1.
157 – 427 Missing. In isoform D2.
215 – 219
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-215 AND THR-293;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.