Variant position: 210 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 261 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LNFTPEPSDIFSCIVTHEID RYTAIAYWVPRNALPSDLLEN
Mouse LNFTPEPFDLYSCTVTHEID RYTAIAYWVPQNALPSDLLEN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 261 HLA class II histocompatibility antigen, DM alpha chain
27 – 233 Lumenal
121 – 215 Ig-like C1-type
125 – 217 Alpha-2
199 – 199 I -> N. Decreases the interaction with MHCII and peptide exchange.
220 – 220 R -> A. Decreases the interaction with MHCII and peptide exchange; when associated with A-124.
207 – 210
No reference for the current variant in UniProtKB/Swiss-Prot.
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