Variant position: 331 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VLDLFGAGFDTVTTAISWSL MYLVMNPRVQRKIQEELDTVI
Rhesus macaque VLDLFGAGFDTVTTAISWSL MYLVTNPRVQRKIQEELDTVI
Mouse VLDLFGAGFDTVTTAISWSL MYLVTNPRVQRKIQEELDTVI
Rat VFDLFGAGFDTITTAISWSL MYLVTNPRIQRKIQEELDTVI
Rabbit VLDLFGAGFDTVTTAISWSL MYLVTKPRIQRKIQEELDAVV
Sheep VMDLFGAGFDTVTTAISWSL LYLVTSPRVQKKIQEELDTVI
Cat VSDLFGAGFDTVTTAISWCL MYLVTSPNVQEKIQKELDTVI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 512 Cytochrome P450 1A1
190 – 512 Missing. In isoform 2.
310 – 334
Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population.
Chevalier D.; Allorge D.; Lo-Guidice J.-M.; Cauffiez C.; Lhermitte M.; Lafitte J.-J.; Broly F.;
Hum. Mutat. 17:355-355(2001)
Cited for: VARIANTS ILE-331 AND SER-464;
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