Sequence information
Variant position: 464 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
SEKVIIFGMGKRKCIGETIA
R WEVFLFLAILLQRVEFSVPL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SEKVIIFGMGKRKCIGETIAR WEVFLFLAILLQRVEFSVPL
SEKVILFGLGKRKCIGETIAR LEVFLFLAILLQQVEFSVPE
Rhesus macaque SEKVILFGLGKRKCIGETIAR WEVFLFLAILLQRVEFSVPP
Mouse SEKVTLFGLGKRKCIGETIGR SEVFLFLAILLQQIEFKVSP
Rat SEKVILFGLGKRKCIGETIGR LEVFLFLAILLQQMEFNVSP
Rabbit TEKVLLFGLGKRKCIGETIGR LEVFLFLATLLQQVEFSVSP
Sheep SEKVIIFGLGKRQCIGEIIAR LEVFLFLAILLHQVEFHVTP
Cat SEKVILFGLGKRKCIGETIAR LEVFLFLAILLQQVEFSVPQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 512
Cytochrome P450 1A1
Metal binding
457 – 457
Iron (heme axial ligand)
Alternative sequence
190 – 512
Missing. In isoform 2.
Alternative sequence
419 – 512
Missing. In isoform 3.
Helix
460 – 477
Literature citations
Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population.
Chevalier D.; Allorge D.; Lo-Guidice J.-M.; Cauffiez C.; Lhermitte M.; Lafitte J.-J.; Broly F.;
Hum. Mutat. 17:355-355(2001)
Cited for: VARIANTS ILE-331 AND SER-464;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.