Sequence information
Variant position: 492 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
AILLQRVEFSVPLGVKVDMT
P IYGLTMKHACCEHFQMQLRS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AILLQRVEFSVPLGVKVDMTP IYGLTMKHACCEHFQMQLRS--------
AILLQQVEFSVPEGTKVDMTP IYGLTMKHARCEHFQVRVRT
Rhesus macaque AILLQRVEFSVPPGVKVDMTP IYGLTMKHACCEHFQMQLRS
Mouse AILLQQIEFKVSPGEKVDMTP TYGLTLKHARCEHFQVQMRS
Rat AILLQQMEFNVSPGEKVDMTP AYGLTLKHARCEHFQVQMRS
Rabbit ATLLQQVEFSVSPGTTVDMTP IYGLTMKHARCEHFQAKLRF
Sheep AILLHQVEFHVTPGVKVDMTP LYGLTMKHARCEHFQVRIRS
Cat AILLQQVEFSVPQGTKVDMTP IYGLTMKHARCEHFQVRMRT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 512
Cytochrome P450 1A1
Alternative sequence
190 – 512
Missing. In isoform 2.
Alternative sequence
419 – 512
Missing. In isoform 3.
Literature citations
Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.
Saito M.; Egashira M.; Kiyotani K.; Fujieda M.; Yamazaki H.; Kiyohara C.; Kunitoh H.; Kamataki T.;
Drug Metab. Pharmacokinet. 18:218-222(2003)
Cited for: VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492;
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Solus J.F.; Arietta B.J.; Harris J.R.; Sexton D.P.; Steward J.Q.; McMunn C.; Ihrie P.; Mehall J.M.; Edwards T.L.; Dawson E.P.;
Pharmacogenomics 5:895-931(2004)
Cited for: VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND ARG-492;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.