Variant position: 92 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 267 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DNWDSVTSTFSKLREQLGPV TQEFWDNLEKETEGLRQEMSK
Gorilla DNWDSVTSTFSKLREQLGPV TQEFWDNLEKETEGLRQEMSK
Rhesus macaque DNWDSVTSTVSKLREQLGPV TQEFWDNLEKETEGLRQEMSK
Chimpanzee DNWDSVTSTFSKLREQLGPV TQEFWDNLEKETEGLRQEMSK
Mouse ENWDTLGSTVSQLQERLGPL TRDFWDNLEKETDWVRQEMNK
Rat DNWDTLGSTVGRLQEQLGPV TQEFWANLEKETDWLRNEMNK
Pig DNWDSLGSTFTKVREQLGPV TQEFWDNLEKETEALRQEMSK
Bovine DNWDTLASTLSKVREQLGPV TQEFWDNLEKETASLRQEMHK
Rabbit DNWDSLSSTVSKLQEQLGPV TQEFWDNLEKETEGLREEMNK
Chicken DNLDTLSAAAAKLREDMAPY YKEVREMWLKDTEALRAELTK
Zebrafish ESLTKLQEYAQTTSQALTPY AETISTQLMENTKQLRERVMT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
19 – 267 Proapolipoprotein A-I
25 – 267 Apolipoprotein A-I
25 – 266 Truncated apolipoprotein A-I
90 – 111 2
68 – 267 10 X approximate tandem repeats
110 – 110 Methionine sulfoxide
Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.
Morabia A.; Cayanis E.; Costanza M.C.; Ross B.M.; Flaherty M.S.; Alvin G.B.; Das K.; Gilliam T.C.;
Hum. Mol. Genet. 12:2733-2743(2003)
Cited for: VARIANT ILE-92;
Quantitative detection of single amino acid polymorphisms by targeted proteomics.
Su Z.D.; Sun L.; Yu D.X.; Li R.X.; Li H.X.; Yu Z.J.; Sheng Q.H.; Lin X.; Zeng R.; Wu J.R.;
J. Mol. Cell Biol. 3:309-315(2011)
Cited for: VARIANT ILE-92; IDENTIFICATION BY MASS SPECTROMETRY;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.