Variant position: 364 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 484 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AFLTADTILNTLQNISEGLV VYPKVIERRIRQELPFMATEN
Mouse AFLTADTILNTLQNISEGLV VYPKVIERRIRQELPFMATEN
Bovine AFLTADTVLNTLQNISEGLV VYPKVIERRVQQELPFMATEN
Chicken AFLTADIILSTLQNISEGLV VYPKVIDRRIRQELPFMATEN
Caenorhabditis elegans VLLTAEALLTTLQNIFEGLS VQTDNVKKIVEDEIAFLGLEK
Slime mold PFSHSILSFKSIQRGLSKLV LNEANIAKDLDANWAVV-SEA
Baker's yeast AFLTADILLSTLLNISSGLV VYPKVIERRIKGELPFMATEN
Fission yeast AFLFTDSVLKILLNVISGMV IYPKVIQKHIRAELPFMATEN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 484 Adenylosuccinate lyase
Screening for adenylosuccinate lyase deficiency: clinical, biochemical and molecular findings in four patients.
Castro M.; Perez-Cerda C.; Merinero B.; Garcia M.J.; Bernar J.; Gil Nagel A.; Torres J.; Bermudez M.; Garavito P.; Marie S.; Vincent F.; Van den Berghe G.; Ugarte M.;
Cited for: VARIANTS ADSLD VAL-311; MET-364; HIS-396 AND PRO-452;
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