Sequence information
Variant position: 423 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 484 The length of the canonical sequence.
Location on the sequence:
IRVLSQQAASVVKQEGGDND
L IERIQVDAYFSPIHSQLDHL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IRVLSQQAASVVKQEGGDNDL IERIQVDAYFSPIHSQLDHL
Mouse IRVLSQQAAAVVKQEGGDNDL IERIRADAYFSPIHSQLEHL
Bovine IRVLSQQAAAVVKQEGGDNDL IERIQADAYFSPIHSQLDHL
Chicken IRVLSQQAAAVVKQEGGDNDF IARVRADPYFSPIHEHLDSL
Caenorhabditis elegans IRKTALEAKQLQATQKVD--- IRQTMADPFFDSVRDRVVGL
Slime mold LKELTRVSGSKKITESDIQTF IDSLSIP---DDIKSELK-L
Baker's yeast IRVLSHQAAAVVKEEGGENDL IERVKRDEFFKPIWEELDSL
Fission yeast IRVLSHQAGRVVKEEGGDNDL IERIKNTPYFAPIYDELDSL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 484
Adenylosuccinate lyase
Cross
415 – 415
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Alternative sequence
398 – 456
Missing. In isoform 2.
Helix
423 – 429
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.